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KMID : 1377020150120060457
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Tissue Engineering and Regenerative Medicine
2015 Volume.12 No. 6 p.457 ~ p.463
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Regenerative effect of the polydeoxyribonucleotide after sciatic nerve transection in mouse
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Park Ji-Woen
Kim Min-Su
Kim Seok-Kwun
Lee Keun-Cheol
Lee Jin-Wha
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Abstract
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Factors that have effects on postoperative nerve regeneration are surgery period, maneuver and the use of material that promotes nerve regeneration. Of various materials that promote nerve regeneration, vascular endothelial growth factor (VEGF) is known as cytokine that plays an important role in regenerating not only vessels but also nerves. Polydeoxyribonucleotide (PDRN) promotes the synthesis of VEGF. Thus, assuming that PDRN has the effect of peripheral nerve regeneration, mice were classified into a group with PDRN being administered, a group with VEGF being administered, and a group with nothing administered. Placentex® (PDRN) and VEGF were used, and 40 male mice were used. Then, the mice were classified into two test groups with Placentex® and VEGF injection, and the control group with NaCl 0.9%. After 2 and 4 weeks, the mice were killed and their histological examination was conducted through electron microscope. It revealed that each group was insignificantly different in terms of all comparative items, but the finding after 4 weeks revealed that the test group with PDRN and VEGF showed a statistically significant effect of promoting nerve regeneration. Further, all histological examinations found that the group with PDRN and VEGF promoted nerve regeneration. Regarding the period, the group with VEGF, compared to the PDRN group, showed a better result, but the difference proved to be statistically insignificant. It was confirmed that PDRN had the effect of promoting nerve regeneration; thus PDRN can help restore peripheral nerve damage, caused by trauma and surgery, and promote the prognosis.
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KEYWORD
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Vascular endothelial growth factor, Polydeoxyribonucleotide, Peripheral nerve, Nerve regeneration, Regenerative effect
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